Boosters offer great protection against omicron, new data confirms. Which one should you choose?

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While the definition of “fully vaccinated” hasn’t changed, by the US Centers for Disease Control and Prevention until you received your COVID-19 booster shot (when you’re eligible for it). That’s because increasing evidence shows boosters are needed to restore protection against the new omicron variant, which has reduced the vaccines’ effectiveness against COVID-19 infection. 

However, two reports published Friday by the CDC revealed good news about how our boosters are holding up against omicron, and how the vaccines continue to protect against hospitalization caused by COVID-19. When the omicron variant was emerging in the US, adults who received a booster shot were compared to unvaccinated adults. Third doses or terbaik sumatera boosters of Pfizer or Moderna were also with COVID-19 when omicron was emerging, the CDC found.

Everyone aged 12 and older is eligible for a booster. Recently, the CDC even shortened the period of time someone who got Pfizer’s or Moderna’s vaccine needs to wait for a booster, . (People who received Johnson & Johnson’s vaccine should still get a booster at least two months after their one-dose vaccine.) 

The booster recommendation is clear now (get one), but the guidance leaves a little choice up to you. While the CDC recommended that everyone receive a booster dose of Pfizer’s or Moderna’s vaccine ( over Johnson & Johnson’s in most cases, the CDC says, even if you originally got the J&J). That’s because people are now able to “mix and match” COVID-19 vaccines after were authorized by the US Food and Drug Administration.

While the world continues to watch the coronavirus and scientists accordingly, here’s what to know about choosing a booster. 


shows that, in December, unvaccinated adults ages 50 to 64 years were 44 times more likely to be hospitalized with COVID-19 compared to adults who were fully vaccinated and boosted. The risk was even higher, 49 times, for adults age 65 or older when compared to the same age group who had been boosted. 

US Centers for Disease Control and Prevention / Screenshot on Jan. 21

How are the COVID-19 vaccines different? 

While all three vaccines have the same effect — protection against severe COVID-19 disease — the way they function is a little different. Pfizer and Moderna are mRNA vaccines, which  and build immunity against a virus. Johnson & Johnson (the only authorized one-dose vaccine) is a viral vector, which  to activate an immune response that teachers our bodies what to fight in future infections.

Both vaccine types prepare our immune systems for COVID-19 infection and  infects us with the actual coronavirus. Pfizer’s and Johnson & Johnson’s booster are the same dose as the original vaccines, while Moderna’s booster is half the size of its original vaccine. 

After an outside committee that advises the CDC raised concerns over a that can happen following vaccination with Johnson & Johnson’s vaccine, the CDC recommends people receive Pfizer’s or Moderna’s vaccine or booster instead. However, Johnson & Johnson’s vaccine is still authorized and available for people age 18 and up if they prefer it. 

Does mixing and matching work?

Research available now in the US as well as other countries shows that choosing a different COVID-19 vaccine as a booster is effective. In some cases, mixing and matching seems to produce a stronger response compared with sticking to the original vaccine. 

During a mix-and-match COVID-19 vaccine trial funded by the National Institute of Allergy and Infectious Diseases (before omicron was the dominant variant), boosters from all three vaccine companies in roughly 450 people who got different vaccines. In the study, Moderna’s booster gave the most robust response. However, that study examined a full dose of Moderna, rather than the authorized half-dose of the company’s booster, which , as The Atlantic reported. 

Another of 64 people found that people who originally received Pfizer’s vaccine, but then got a booster of Johnson & Johnson’s vaccine, had a stronger response to Johnson & Johnson’s vaccine. This included the harder-to-measure T-cell immune responses Johnson & Johnson’s vaccine appears to protect with as opposed to antibody response alone — which may be the reason give great protection against hospitalization and disease caused by the omicron variant.  

An earlier study from Spain published in the in May 2021 found that mixing one dose of AstraZeneca (a similar vaccine to Johnson & Johnson’s) with one dose of Pfizer produces a higher antibody response than people who receive two doses of AstraZeneca. It isn’t clear whether this group had a higher immune response than people who received two doses of Pfizer, however. 


The definition of “fully vaccinated” hasn’t changed. A person is considered fully vaccinated two weeks after their second dose of Pfizer or Moderna, or two weeks after a single dose of Johnson & Johnson. 

Sarah Tew/CNET

Which booster shot should I get? 

No matter which COVID-19 vaccine you originally got (Pfizer, Moderna or Johnson & Johnson), you should get a booster of Moderna’s or Pfizer’s vaccine,  Kids and teens ages 12 to 17 should get a Pfizer booster, however, because Pfizer is the only COVID-19 vaccine authorized for people under age 18. 

The preference for either mRNA vaccine followed concerns of a rare but serious blood-clotting disorder associated with Johnson & Johnson’s vaccine, called . Since the CDC paused the distribution of the disorder to investigate, more information revealed that it’s less rare than previously understood and occurs in both men and women. (Although still rare over all, occurring in  of Johnson & Johnson given, per the CDC, women ages 30 to 49 are at higher risk of the disorder with about  experiencing it). Nine people have died from TTS and all cases required hospitalization or ICU admission, according to a . 

Johnson & Johnson’s vaccine is available to you if you prefer it for any reason, or if you can’t take Moderna’s or Pfizer’s because of an allergy. But given the excellent safety and wide availability of Pfizer’s and Moderna’s vaccine, the CDC made the recommendation in line with that other countries have done for AstraZeneca’s vaccine, which is associated with the same rare issue. 

A  in September (before omicron) compared vaccine effectiveness in the real world found that two doses of Moderna’s vaccine was 93% effective at preventing hospitalization, two doses of Pfizer were 88% effective and one dose of Johnson & Johnson was 71% effective. And while omicron does evade our protection against COVID-19 infection given by the vaccines, . 

According to collected by the CDC, most people who got Pfizer’s or Moderna’s vaccine seem to stick to their original vaccine brand (most people who got Johnson & Johnson’s vaccine originally have gotten a different booster). However, millions of Americans have opted for a different vaccine brand as a booster, and no safety concerns have been raised by either the FDA or CDC in people who’ve mixed and matched. 

Are you fully vaccinated after your booster? 

Importantly, the definition of fully vaccinated hasn’t changed (). You’re still  two weeks after your second Pfizer or Moderna shot or two weeks after your Johnson & Johnson vaccine. Whether someone has received a booster doesn’t affect their “fully vaccinated” status. 

Can I mix and match the first two shots?

No, the CDC’s statement on mixing COVID-19 vaccines only applies to boosters. As of now, the FDA has only authorized a mixed-series booster, meaning the first coronavirus vaccine series must be one dose of Johnson & Johnson or two doses of Moderna or Pfizer. 

Once the mixed-series boosters start rolling out to Americans in greater numbers, there will be more data on the safety and effectiveness of a mixed COVID-19 series. Although it might be too early to hope, this might mean that data on mixing for boosters will inform decisions on primary coronavirus vaccine series being used together, making it easier to reach underserved communities, and possibly reducing health care and vaccine inequity.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.

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